{"id":3222,"date":"2023-12-29T10:02:37","date_gmt":"2023-12-29T10:02:37","guid":{"rendered":"https:\/\/scientificworld.org\/?p=3222"},"modified":"2025-03-17T07:30:52","modified_gmt":"2025-03-17T07:30:52","slug":"guarding-the-heart-how-a-new-discovery-fights-heart-enlargement","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=3222","title":{"rendered":"Guarding the Heart: How a New Discovery Fights Heart Enlargement!"},"content":{"rendered":"\n<p><a href=\"https:\/\/tmr.scione.com\/cms\/fulltext.php?id=123\" target=\"_blank\" rel=\"noreferrer noopener\">Trends in Medical Research<\/a> published a research work conducted by Junjun Shang, investigates the impact of Toll-Like Receptor 4 (TLR4) on Angiotensin II (Ang II)-induced cardiac hypertrophy in mice. The study explores the application of TAK-242, a TLR4 inhibitor, and its effects on various cardiac parameters. Results show that TAK-242 reduces heart mass index, cardiac-tibial ratio, cardiomyocyte cross-sectional area, and ameliorates fibrosis. It inhibits the expression of vimentin and TLR4, thereby reducing Ang II-induced cardiac hypertrophy. The study suggests that TLR4 is a key target in cardiac hypertrophy, providing new insights for clinical treatment and potential drug development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trends in Medical Research published a research work conducted by Junjun Shang, investigates the impact of Toll-Like Receptor 4 (TLR4) on Angiotensin II (Ang II)-induced cardiac hypertrophy in mice. The study explores the application of TAK-242, a TLR4 inhibitor, and its effects on various cardiac parameters. Results show that TAK-242 reduces heart mass index, cardiac-tibial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3223,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[1003,1001,998],"class_list":["post-3222","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-trending","tag-cardiac-hypertrophy","tag-cardiac-tibial-ratio","tag-heart-enlargement"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3222"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3222\/revisions"}],"predecessor-version":[{"id":3224,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3222\/revisions\/3224"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/media\/3223"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}