{"id":3485,"date":"2025-04-05T11:20:28","date_gmt":"2025-04-05T11:20:28","guid":{"rendered":"https:\/\/scientificworld.org\/?p=3485"},"modified":"2025-04-05T11:20:30","modified_gmt":"2025-04-05T11:20:30","slug":"l-draba-extract-shows-promise-in-protecting-liver-and-kidney-from-chemotherapy-side-effects","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=3485","title":{"rendered":"L. draba Extract Shows Promise in Protecting Liver and Kidney from Chemotherapy Side Effects"},"content":{"rendered":"\n<p>A recent study reveals that&nbsp;<em>Lepidium draba L.<\/em>&nbsp;(<em>L. draba<\/em>) extract may shield the liver and kidneys from damage caused by cyclophosphamide (CP), a common chemotherapy drug. Published by researchers including Yu-Lai You and Sheng Zheng in <a href=\"http:\/\/dx.doi.org\/10.4103\/apjtb.apjtb_518_24\">Asian Pacific Journal of Tropical Biomedicine<\/a>, the study demonstrates how the extract reduces oxidative stress, inflammation, and cell death in rats. These findings could lead to new therapies for mitigating chemotherapy-induced toxicity.<\/p>\n\n\n\n<p>The research team divided 36 rats into six groups, including a control group, a CP-treated group, and groups receiving varying doses of <em>L. draba<\/em> extract alongside CP. The extract significantly lowered markers of liver and kidney damage, such as nitric oxide and pro-inflammatory cytokines (IL-6, TNF-\u03b1, and IL-1\u03b2), while boosting antioxidant enzymes like superoxide dismutase.<\/p>\n\n\n\n<p>Key findings include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Reduced apoptosis: The extract downregulated pro-apoptotic genes (<em>Bax<\/em>\u00a0and\u00a0<em>caspase-3<\/em>) and preserved tissue structure in the liver and kidneys.<\/li>\n\n\n\n<li>Anti-inflammatory effects: Levels of protective cytokines (TGF-\u03b2) increased, countering CP-induced inflammation.<\/li>\n\n\n\n<li>Histopathological improvements: The extract mitigated damage to renal tubules and hepatocytes, as seen in microscopic analyses.<\/li>\n<\/ul>\n\n\n\n<p><em>&#8220;L. draba extract not only combats oxidative stress but also addresses the inflammatory and apoptotic pathways triggered by cyclophosphamide,&#8221;<\/em>&nbsp;noted the authors.<\/p>\n\n\n\n<p>The study highlights <em>L. draba<\/em> extract\u2019s potential as a complementary therapy to protect organs during chemotherapy. Future research will explore its applicability in human trials, offering hope for reducing the adverse effects of cancer treatments.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study reveals that&nbsp;Lepidium draba L.&nbsp;(L. draba) extract may shield the liver and kidneys from damage caused by cyclophosphamide (CP), a common chemotherapy drug. Published by researchers including Yu-Lai You and Sheng Zheng in Asian Pacific Journal of Tropical Biomedicine, the study demonstrates how the extract reduces oxidative stress, inflammation, and cell death in [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1221],"tags":[726,1344],"class_list":["post-3485","post","type-post","status-publish","format-standard","hentry","category-health-sciences","tag-health","tag-kidney"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3485"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3485\/revisions"}],"predecessor-version":[{"id":3486,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/3485\/revisions\/3486"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}