{"id":4140,"date":"2025-05-23T10:31:49","date_gmt":"2025-05-23T10:31:49","guid":{"rendered":"https:\/\/scientificworld.org\/?p=4140"},"modified":"2025-05-23T10:31:53","modified_gmt":"2025-05-23T10:31:53","slug":"obesity-disrupts-timing-of-metabolic-response-to-starvation-in-mice","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=4140","title":{"rendered":"Obesity Disrupts Timing of Metabolic Response to Starvation in Mice"},"content":{"rendered":"\n<p>Researchers at the University of Tokyo have discovered that obesity disrupts the timing of metabolic responses to starvation in mice, even though the structure of the molecular network remains intact. Led by Keigo Morita and Shinya Kuroda, the study highlights the importance of temporal coordination in metabolism and opens new avenues for understanding broader metabolic processes, such as food intake and disease progression. The findings were published in the journal&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1126\/scisignal.ads2547\"><em>Science Signaling<\/em><\/a>.<\/p>\n\n\n\n<p>The study focused on how the liver, a central player in metabolism, coordinates molecular activity during starvation. In healthy mice, key energy-related molecules like ATP and AMP acted as &#8220;hubs,&#8221; responding rapidly to starvation and maintaining a well-controlled temporal order. However, in obese mice, this rapid response was lost, disrupting the timing of metabolic adaptation without affecting the network&#8217;s structure.<\/p>\n\n\n\n<p>Shinya Kuroda, the principal investigator, explained, &#8220;Hub molecules in healthy livers reacted quickly to starvation, ensuring efficient energy distribution. But in obese mice, this coordination vanished, making their metabolism temporally vulnerable.&#8221; The team achieved these insights by analyzing comprehensive time-series data, a breakthrough in field where temporal research has been historically challenging.<\/p>\n\n\n\n<p>The study&#8217;s innovative approach, combining structural and temporal analysis, could be applied to other complex biological systems, such as the genome or microbiome. Kuroda added, &#8220;Our method provides a framework for studying metabolic networks during food intake or disease progression, offering broader implications for health research.&#8221;<\/p>\n\n\n\n<p>This research underscores the critical role of timing in metabolic processes and how obesity can impair this coordination. By revealing these temporal disruptions, the study paves the way for future investigations into metabolic diseases and potential interventions. The team plans to extend their findings to other metabolic scenarios, advancing our understanding of health and disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of Tokyo have discovered that obesity disrupts the timing of metabolic responses to starvation in mice, even though the structure of the molecular network remains intact. Led by Keigo Morita and Shinya Kuroda, the study highlights the importance of temporal coordination in metabolism and opens new avenues for understanding broader metabolic [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1367],"tags":[1368,213,1819],"class_list":["post-4140","post","type-post","status-publish","format-standard","hentry","category-biology","tag-biology","tag-obesity","tag-starvation"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4140"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4140\/revisions"}],"predecessor-version":[{"id":4141,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4140\/revisions\/4141"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}