{"id":4438,"date":"2025-06-13T10:30:57","date_gmt":"2025-06-13T10:30:57","guid":{"rendered":"https:\/\/scientificworld.org\/?p=4438"},"modified":"2025-06-13T10:31:01","modified_gmt":"2025-06-13T10:31:01","slug":"no-cognitive-difference-found-between-blood-pressure-strategies-after-noncardiac-surgery","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=4438","title":{"rendered":"No Cognitive Difference Found Between Blood Pressure Strategies After Noncardiac Surgery"},"content":{"rendered":"\n<p>A large randomized controlled trial has found no significant differences in cognitive outcomes between hypotension-avoidance and hypertension-avoidance strategies during noncardiac surgery. The study, published in&nbsp;<a href=\"http:\/\/dx.doi.org\/10.7326\/ANNALS-24-02841\"><em>Annals of Internal Medicine<\/em><\/a>, involved 2,603 high-risk patients across 19 countries and revealed similar rates of postoperative delirium and one-year cognitive decline in both groups. These findings challenge the need for specific blood pressure targets to protect brain function after surgery.<\/p>\n\n\n\n<p>The trial, conducted by researchers from McMaster University, Population Health Research Institute, Humanitas University, and colleagues, compared two perioperative blood pressure management approaches. One strategy aimed to avoid hypotension (targeting a mean arterial pressure [MAP] \u226580 mm Hg and withholding certain antihypertensive medications), while the other focused on avoiding hypertension (targeting MAP \u226560 mm Hg and continuing all antihypertensive drugs).<\/p>\n\n\n\n<p>Delirium occurred in 7.3% of the hypotension-avoidance group and 7% of the hypertension-avoidance group, with no difference in severity. Similarly, cognitive decline one year after surgery was comparable between the two groups. The study, the largest of its kind, underscores that neither strategy offers a distinct advantage for neurocognitive outcomes.<\/p>\n\n\n\n<p><em>&#8220;Our results suggest that clinicians can use either blood pressure management strategy without affecting cognitive recovery,&#8221;<\/em>&nbsp;said the lead author.&nbsp;<em>&#8220;This simplifies decision-making for high-risk patients undergoing major surgery.&#8221;<\/em><\/p>\n\n\n\n<p>The findings indicate that tailoring blood pressure targets or antihypertensive medication management during noncardiac surgery may not be necessary to prevent cognitive complications. Future research could explore other factors influencing postoperative brain health.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A large randomized controlled trial has found no significant differences in cognitive outcomes between hypotension-avoidance and hypertension-avoidance strategies during noncardiac surgery. The study, published in&nbsp;Annals of Internal Medicine, involved 2,603 high-risk patients across 19 countries and revealed similar rates of postoperative delirium and one-year cognitive decline in both groups. These findings challenge the need for [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1565],"tags":[1566,1974],"class_list":["post-4438","post","type-post","status-publish","format-standard","hentry","category-health-medicine","tag-health-medicine","tag-noncardiac-surgery"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4438"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4438\/revisions"}],"predecessor-version":[{"id":4439,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4438\/revisions\/4439"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}