{"id":4546,"date":"2025-06-23T09:41:40","date_gmt":"2025-06-23T09:41:40","guid":{"rendered":"https:\/\/scientificworld.org\/?p=4546"},"modified":"2025-06-23T09:42:42","modified_gmt":"2025-06-23T09:42:42","slug":"childhood-cancer-survivors-face-unique-genetic-risks-for-late-onset-cardiomyopathy","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=4546","title":{"rendered":"Childhood Cancer Survivors Face Unique Genetic Risks for Late-Onset Cardiomyopathy"},"content":{"rendered":"\n<p>Scientists from St. Jude Children\u2019s Research Hospital have uncovered distinct genetic factors influencing the risk of late-onset cardiomyopathy in childhood cancer survivors. Published in&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1001\/jamanetworkopen.2025.15793\"><em>JAMA Network Open<\/em><\/a>, the study shows that while common variants in&nbsp;<em>TTN<\/em>&nbsp;and&nbsp;<em>BAG3<\/em>&nbsp;genes reduce cardiomyopathy risk\u2014mirroring trends in the general population\u2014rare variants linked to early-onset cases in adults do not apply to these survivors. The findings highlight the unique challenges faced by long-term childhood cancer survivors.<\/p>\n\n\n\n<p>Childhood cancer survivors are 15 times more likely to develop cardiomyopathy than their healthy siblings, a risk exacerbated by cancer treatments, young age at diagnosis, and traditional heart disease factors. Yet, these elements alone don\u2019t fully explain the heightened risk, prompting researchers to explore genetic contributors.<\/p>\n\n\n\n<p>Led by Dr. Yadav Sapkota, the team analyzed data from 453 survivors across two cohorts, focusing on&nbsp;<em>TTN<\/em>&nbsp;(which produces the structural protein titin) and&nbsp;<em>BAG3<\/em>&nbsp;(a regulatory protein). They discovered that common variants in these genes lowered the risk of late-onset cardiomyopathy, aligning with patterns seen in the general population. However, rare variants associated with early-onset cardiomyopathy in adults showed no effect in childhood survivors, underscoring the distinct genetic landscape of this group.<\/p>\n\n\n\n<p>Dr. Sapkota explained, \u201cIn familial cases, rare variants often cause early-onset disease. But for late-onset cardiomyopathy in survivors, common variants with modest effects play a bigger role, similar to sporadic cases in the general population.\u201d<\/p>\n\n\n\n<p>The study emphasizes the need for tailored genetic screening to better assess cardiomyopathy risk in childhood cancer survivors. By recognizing the differences between early- and late-onset disease mechanisms, researchers aim to improve future risk prediction and personalized care for this vulnerable population.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from St. Jude Children\u2019s Research Hospital have uncovered distinct genetic factors influencing the risk of late-onset cardiomyopathy in childhood cancer survivors. Published in&nbsp;JAMA Network Open, the study shows that while common variants in&nbsp;TTN&nbsp;and&nbsp;BAG3&nbsp;genes reduce cardiomyopathy risk\u2014mirroring trends in the general population\u2014rare variants linked to early-onset cases in adults do not apply to these survivors. [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1565],"tags":[2029,1566],"class_list":["post-4546","post","type-post","status-publish","format-standard","hentry","category-health-medicine","tag-cardiomyopathy","tag-health-medicine"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4546"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4546\/revisions"}],"predecessor-version":[{"id":4547,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4546\/revisions\/4547"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}