{"id":4614,"date":"2025-06-27T10:11:46","date_gmt":"2025-06-27T10:11:46","guid":{"rendered":"https:\/\/scientificworld.org\/?p=4614"},"modified":"2025-06-27T10:11:48","modified_gmt":"2025-06-27T10:11:48","slug":"breakthrough-study-repurposed-cancer-drugs-show-promise-in-stroke-recovery","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=4614","title":{"rendered":"Breakthrough Study: Repurposed Cancer Drugs Show Promise in Stroke Recovery"},"content":{"rendered":"\n<p>A groundbreaking study by researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has revealed that a class of cancer drugs, histone deacetylase inhibitors (HDACi), can significantly reduce brain damage and promote recovery after stroke. Published in the journal&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1002\/glia.70035\"><em>GLIA<\/em><\/a>, the findings offer hope for new treatment strategies that address the secondary inflammation following stroke, a leading cause of disability and death worldwide.<\/p>\n\n\n\n<p>The study demonstrated that HDACi drugs, already used or tested for cancer and neurodegenerative diseases like Alzheimer\u2019s, can reprogram microglia\u2014the brain\u2019s immune cells\u2014from an inflammatory state to a protective one. In laboratory models simulating stroke, HDACi treatment reduced brain damage by 60% and improved behavioral outcomes. Advanced techniques like spatial transcriptomics revealed how these drugs restore neuroprotective gene activity in specific brain regions, including the hippocampus, which is critical for memory.<\/p>\n\n\n\n<p>Current stroke therapies focus primarily on restoring blood flow and are time-sensitive. This research opens the door to treatments that target the harmful inflammation occurring days after a stroke, potentially extending the therapeutic window. Professor S Thameem Dheen, the lead author, emphasized the clinical potential: \u201cHDACi can dampen brain inflammation and promote recovery through a microglia-centric mechanism.\u201d<\/p>\n\n\n\n<p>The team aims to develop therapies that act beyond the acute phase of stroke, repairing brain circuitry and preserving function. Co-author Dr. Kevin Jayaraj highlighted the broader implications: \u201cOur findings represent an out-of-the-box approach for conditions where neuroinflammation plays a key role.\u201d<\/p>\n\n\n\n<p>This study marks a significant step toward innovative stroke treatments, offering new hope for patients and clinicians alike.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A groundbreaking study by researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), has revealed that a class of cancer drugs, histone deacetylase inhibitors (HDACi), can significantly reduce brain damage and promote recovery after stroke. Published in the journal&nbsp;GLIA, the findings offer hope for new treatment strategies that address [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1565],"tags":[2061,1566],"class_list":["post-4614","post","type-post","status-publish","format-standard","hentry","category-health-medicine","tag-cancer-drugs","tag-health-medicine"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4614"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4614\/revisions"}],"predecessor-version":[{"id":4615,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/4614\/revisions\/4615"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}