{"id":5300,"date":"2025-07-15T07:50:14","date_gmt":"2025-07-15T07:50:14","guid":{"rendered":"https:\/\/scientificworld.org\/?p=5300"},"modified":"2025-07-15T07:50:21","modified_gmt":"2025-07-15T07:50:21","slug":"new-study-reveals-over-200-misfolded-proteins-linked-to-alzheimers-and-dementia","status":"publish","type":"post","link":"https:\/\/scientificworld.org\/?p=5300","title":{"rendered":"New Study Reveals Over 200 Misfolded Proteins Linked to Alzheimer\u2019s and Dementia"},"content":{"rendered":"\n<p>A groundbreaking study from Johns Hopkins University suggests that more than 200 types of misfolded proteins, beyond the well-known A-beta and tau amyloids, may contribute to age-related cognitive decline. Published in&nbsp;<a href=\"http:\/\/dx.doi.org\/10.1126\/sciadv.adt3778\"><em>Science Advances<\/em><\/a>, the findings could open new avenues for treating Alzheimer\u2019s and dementia, which affect millions of people over 65 worldwide.<\/p>\n\n\n\n<p>Researchers studied 17 aging rats, comparing those with cognitive impairment to those with sharp mental function. By analyzing over 2,500 proteins in the hippocampus\u2014the brain region critical for memory\u2014they identified more than 200 proteins that misfolded only in impaired rats. These proteins, unlike amyloids, do not clump together but still disrupt brain function.<\/p>\n\n\n\n<p>\u201cAmyloids are big and easy to see, but our work shows they\u2019re just the tip of the iceberg,\u201d said lead researcher Stephen Fried, a protein scientist at Johns Hopkins. \u201cMany misfolded proteins evade the cell\u2019s cleanup system, potentially harming cognitive health.\u201d<\/p>\n\n\n\n<p>The study challenges the long-held focus on amyloids alone, suggesting a broader range of proteins may play a role in dementia. Next, the team will examine these proteins at the molecular level to understand how they evade cellular defenses.<\/p>\n\n\n\n<p>\u201cUnderstanding these mechanisms could lead to better treatments,\u201d Fried added, emphasizing the urgency of addressing cognitive decline in aging populations.<\/p>\n\n\n\n<p>This research marks a significant step toward uncovering the complex causes of Alzheimer\u2019s and dementia, offering hope for future therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A groundbreaking study from Johns Hopkins University suggests that more than 200 types of misfolded proteins, beyond the well-known A-beta and tau amyloids, may contribute to age-related cognitive decline. Published in&nbsp;Science Advances, the findings could open new avenues for treating Alzheimer\u2019s and dementia, which affect millions of people over 65 worldwide. Researchers studied 17 aging [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1093],"tags":[2799,2800,1938,1875,1566,1433],"class_list":["post-5300","post","type-post","status-publish","format-standard","hentry","category-neuroscience","tag-alzheimer-disease","tag-brain-region","tag-dementia","tag-disease-detection","tag-health-medicine","tag-neuroscience"],"_links":{"self":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/5300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5300"}],"version-history":[{"count":1,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/5300\/revisions"}],"predecessor-version":[{"id":5301,"href":"https:\/\/scientificworld.org\/index.php?rest_route=\/wp\/v2\/posts\/5300\/revisions\/5301"}],"wp:attachment":[{"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scientificworld.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}