Scientists have discovered that precise terahertz (THz) photon stimulation can enhance neuronal growth and improve cognitive abilities in mice. A study published in PhotoniX reveals that 34.5 THz photons promote hippocampal neurite outgrowth and synaptogenesis by activating a key brain enzyme, adenylyl cyclase 1 (AC1). This non-invasive approach could pave the way for novel therapies to treat cognitive disorders.
The research, led by Rundong Jiang and colleagues, demonstrated that 34.5 THz photon exposure increased neurite branching by 17% and elevated levels of postsynaptic density protein (PSD95) by 26% in hippocampal neurons. These changes were linked to a 45.9% rise in cAMP, a molecule critical for neuronal signaling, driven by THz photons resonating with AC1. Molecular simulations showed this resonance strengthened ATP binding to AC1, accelerating cAMP production.
Unlike drug-based methods, this technique avoids thermal effects or chemical side effects. Behavioral tests confirmed that treated mice exhibited improved learning and memory, underscoring their potential for clinical applications.
“Our findings suggest THz modulation could revolutionize how we address cognitive decline,” said Dr. Jiang. “By targeting AC1, we’ve unlocked a physical method to enhance brain function.”
The study highlights THz photon therapy as a promising, non-invasive tool to boost cognition. Future research will explore its efficacy in humans and potential applications for neurodegenerative diseases.
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