Scientists at Mass General Brigham have pinpointed the ideal location in the brain to target during MRI-guided focused ultrasound (MRgFUS) treatment for essential tremor, a neurological disorder affecting millions worldwide. Published in Science Advances, their findings could enhance the safety and effectiveness of this noninvasive procedure, offering long-lasting relief to patients.
The study analyzed data from 351 patients treated with MRgFUS across three international hospitals, the largest cohort to date. Researchers identified a specific subregion of the thalamus, the brain’s relay center, that, when targeted, maximizes tremor improvement while minimizing side effects. By creating a model of this “sweet spot,” the team demonstrated its predictive power for patient outcomes, with better results observed when the target was accurately lesioned.
MRgFUS thalamotomy, pioneered at Brigham and Women’s Hospital 30 years ago, involves creating a small, permanent lesion in the thalamus to disrupt tremor-causing brain activity. The new study not only refines the procedure’s precision but also provides a roadmap for other medical centers to replicate its success.
“This one-time, noninvasive treatment can have immediate, long-lasting, and life-changing effects for patients,” said Dr. G. Rees Cosgrove, co-senior author and director of functional neurosurgery at Brigham and Women’s Hospital. Lead author Dr. Melissa Chua added, “It’s exciting to move toward making this treatment even more precise and personalized.”
The research marks a significant step forward in improving MRgFUS for essential tremor, a condition that disrupts daily activities like eating and writing. Future studies will further refine the technique, aiming to optimize long-term outcomes for patients globally.
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